Listeria monocytogenes Meningitis in Adults: The Czech Republic Experience
نویسندگان
چکیده
BACKGROUND Listeria monocytogenes (LM) is currently the third most frequent pathogen of bacterial meningitis in adults. METHODS A prospective study of patients with LM meningitis in a Czech tertiary care hospital, carried out from 1997 to 2012. RESULTS Thirty-one patients were diagnosed with LM meningitis, which was 7% of a total of 440 adult patients with acute bacterial meningitis (ABM) over a 16-year period. Their median age was 63 years, range 26-80 years. Nineteen patients (61%) had underlying immunocompromising comorbidity; 15 patients (48%) were older than 65 years. Fourteen patients (45%) had arterial hypertension. The typical triad of fever, neck stiffness, and altered mental status was present in 21 patients (68%). The median count of cerebrospinal fluid (CSF) leukocytes was 680/μL, protein level 2.6 g/L, and glucose ratio 0.28. Four patients (13%) died, and nine (29%) survived with moderate to severe sequelae. CONCLUSION LM meningitis is known to affect immunosuppressed and elderly patients. Arterial hypertension seems to be another important predisposing factor. Clinical symptoms, CSF findings, and disease outcomes, did not significantly differ from other community-acquired ABM in our study, although the CSF leukocyte count was lower. Ampicillin showed good clinical and bacteriological efficacy in the majority of patients.
منابع مشابه
Listeria monocytogenes meningitis in an immunocompetent adult: a case report.
Listeria monocytogenes (L. monocytogenes) is an uncommon cause of bacterial meningitis in immunocompetent adults. Patients with immunosuppression are at increased risk of developing serious invasive diseases, particularly meningitis. We describe a case of meningitis caused by L. monocytogenes in an immunocompetent and previously healthy 34-year-old adult. The patient received treatment with int...
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1. Hearmon, C.J. & Ghosh, S.K. Listeria monocytogenes meningitis in previously healthy adults. Postgrad Med J 1989, 65: 74-78. 2. Bach, M.C. & Davis, K.M. Listeria rhombencephalitis mimicking tuberculous meningitis. Rev Infect Dis 1987, 9: 130-133. 3. Klein, N.C., Damsker, B. & Hirshman, S.Z. Mycobacterial meningitis. Retrospective analysis from 1970 to 1983. Am J Med 1985, 79: 29-34. 4. Doming...
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ورودعنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013